Anatomy The House of Life (1878) An Atlas of Anatomy (1879) Animal Physiology for Elementary Schools (1882). This makes it more difficult to compare, reproduce and realize the full implications of the various findings.įlorence Miller Jump to. As is typical in the early phase of a new field, research is performed using a multitude of techniques and assumptions, without adhering to any established principled approaches. The knowledge that may be derived from such analyses is, however, presently only harvested to a small degree. These elements can often best be understood as acting in concert in a complex genomic setting, and research into functional information typically involves integrational aspects. As complete human genomic information at the detail of the ENCODE project is being made available for the full genome, it is becoming possible to query relations between many organizational and informational elements embedded in the DNA code. The combination of high-throughput molecular techniques and deep DNA sequencing is now generating detailed genome-wide information at an unprecedented scale. The Genomic HyperBrowser implements the approach and is available.

We provide a growing collection of generic biological investigations that query pairwise relations between tracks, represented as mathematical objects, along the genome. We propose a first principled approach to statistical analysis of sequence-level genomic information.

The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power.

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